An open-label extension study to investigate the long-term safety and tolerability of THC/CBD oromucosal spray and oromucosal THC spray in patients with terminal cancer-related pain refractory to strong opioid analgesics

Alternate title: 
J2 - J Pain Symptom Manage
Secondary title: 
T2 - Journal of Pain & Symptom Management
Short title: 
An open-label extension study to investigate the long-term safety and tolerability of THC/CBD oromucosal spray and oromucosal THC spray in patients with terminal cancer-related pain refractory to strong opioid analgesics
Authors: 
Johnson, Jeremy R.
Lossignol, Dominique
Burnell-Nugent, Mary
Fallon, Marie T.
Volume: 
46
Start page: 
207-18
Annotations: 
Type B, Priority 5,
Date: 
Aug
Year: 
2013
Accession number: 
23141881
Database: 
MEDLINE RCT
Number: 
M1 - 2
Serial: 
1873-6513
Type of work: 
M3 - Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
ID: 
12294
DOI: 
http://dx.doi.org/10.1016/j.jpainsymman.2012.07.014
Notes: 
N1 - Johnson JR
Lossignol D
Burnell-Nugent M
Fallon MT
S0885-3924(12)00439-3
Key words: 
Administration, Oral
Aerosols/ad [Administration & Dosage]
Aerosols/ae [Adverse Effects]
Analgesics, Non-Narcotic/ad [Administration & Dosage]
Analgesics, Non-Narcotic/ae [Adverse Effects]
Analgesics, Opioid/ae [Adverse Effects]
Analgesics, Opioid/tu [Therapeutic Use]
Belgium/ep [Epidemiology]
Dose-Response Relationship, Drug
*Dronabinol/ad [Administration & Dosage]
*Dronabinol/ae [Adverse Effects]
Drug Tolerance
Female
Follow-Up Studies
Great Britain/ep [Epidemiology]
Humans
Longitudinal Studies
Male
Middle Aged
*Neoplasms/co [Complications]
Neoplasms/di [Diagnosis]
*Neoplasms/nu [Nursing]
Pain Measurement/de [Drug Effects]
Pain, Intractable/di [Diagnosis]
*Pain, Intractable/dt [Drug Therapy]
*Pain, Intractable/et [Etiology]
*Palliative Care/mt [Methods]
Terminal Care/mt [Methods]
Treatment Failure
Treatment Outcome
0 (Aerosols)
0 (Analgesics, Non-Narcotic)
0 (Analgesics, Opioid)
7J8897W37S (Dronabinol)
Types of evidence: 
Type B
Priorities of Care: 
Priority 5: Plan and do