Methylnaltrexone for opioid-induced constipation in advanced illness

Secondary title: 
T2 - New England journal of medicine
Short title: 
Methylnaltrexone for opioid-induced constipation in advanced illness
Authors: 
Thomas, J.
Karver, S.
Cooney, G. A.
Chamberlain, B. H.
Watt, C. K.
Slatkin, N. E.
Stambler, N.
Kremer, A. B.
Israel, R. J.
Start page: 
2332-43
Annotations: 
Type B, Priority 5
Year: 
2008
Accession number: 
CN-00639947
Database: 
CENTRAL Issue 4 2014
Number: 
M1 - 22
ID: 
12326
DOI: 
10.1056/NEJMoa0707377 (link)
Notes: 
N1 - Clinical Trial, Phase III; Comment; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Key words: 
Analgesics, Opioid [adverse effects]
Constipation [chemically induced] [drug therapy]
Defecation [drug effects]
Double-Blind Method
Injections, Subcutaneous
Laxatives [adverse effects] [therapeutic use]
Logistic Models
Naltrexone [adverse effects] [analogs & derivatives] [therapeutic use]
Narcotic Antagonists [adverse effects] [therapeutic use]
Quaternary Ammonium Compounds [adverse effects] [therapeutic use]
Terminally Ill
Adult[checkword]
Aged[checkword]
Aged, 80 and over[checkword]
Female[checkword]
Humans[checkword]
Male[checkword]
Middle Aged[checkword]
Sr-ibd: sr-sympt
Types of evidence: 
Type B
Priorities of Care: 
Priority 5: Plan and do